Research Paper: 2009 Mine

Date Published : 01/01/2009

Summary: Intracerebral Hemorrhage and COL4A1 Mutations, from Preterm Infants to Adult Patients.

Abstract: Intracerebral hemorrhage (ICH) accounts for 10% of stroke and is a particularly severe form of stroke. Therapeutic tools are still limited, and prevention remains the most important way to reduce morbidity and mortality. However, for effective prevention, we need to understand the factors underlying the occurrence of hemorrhagic stroke and to identify individuals at greatest risk. Hypertension is a leading factor for ICH in adult patients, and cerebrovascular malformations are the most common causes of ICH in children. How- ever, ICH is a heterogeneous condition, and in a substantial proportion of ICH patients, particularly in the younger ones, no cause can be identified despite extensive investigations.